Based on such evaluation, our Chief Executive Officer and Chief Financial Officer concluded that our disclosure controls and procedures were effective as of December 31, 2025.

filing / Apr 2, 2026 / receipt

Implementation of cost containment measures or other healthcare reforms that affect the pricing and/or availability of drug products may impact our ability to generate revenue, attain or maintain profitability, or commercialize products for which we may receive regulatory approval in the future.

filing / Apr 2, 2026 / receipt

The implementation of cost containment measures or other healthcare reforms may prevent us from being able to generate revenue, attain profitability, or commercialize our drugs.

filing / Apr 2, 2026 / receipt

On June 30, 2024 a lease related to office space in Lexington, Cranberry One Suite 300, expired. The average incremental borrowing rate applied to the lease liability related to the Leiden lease was 7.77 % during the twelve months ended December 31, 2025 and 2024.

filing / Apr 2, 2026 / receipt

Any such violations and consequences could materially damage our reputation, our brand, our international expansion efforts, our ability to attract and retain employees, and our business, prospects, operating results and financial condition.

filing / Apr 2, 2026 / receipt

The increase was primarily driven by the transition from contractors to employees, higher salaries, bonuses, and benefits for existing staff, and the hiring of additional employees to support growth.

filing / Apr 2, 2026 / receipt

Berndt Modig | Chief Executive Officer and Executive Director | 67 | 2015 | 2028

filing / Apr 2, 2026 / receipt

Viviane Monges | Non-Executive Director | 62 | 2021 | 2029

filing / Apr 2, 2026 / receipt

Berndt Modig | Chief Executive Officer and Director | 67 | 2015 | N/A

filing / Apr 2, 2026 / receipt

Annick Deschoolmeester | Chief Human Resources Officer | 53 | 2022 | N/A

filing / Apr 2, 2026 / receipt

David Nassif | Chief Financial Officer, Chief Legal Officer | 71 | 2024 | N/A

filing / Apr 2, 2026 / receipt