Other significant general and administrative expenses include legal fees relating to intellectual property and corporate matters, professional fees for accounting, tax and consulting services, insurance costs, travel expenses and facility related expenses not otherwise included in research and development expenses.

filing / Aug 5, 2026 / receipt

If we are unable to raise capital, we will need to delay, reduce or terminate some or all planned activities to reduce costs.

filing / Aug 5, 2026 / receipt

Outside the United States, international operations are generally subject to extensive governmental price controls and other market regulations, and we believe the increasing emphasis on cost containment initiatives in Europe, Canada and other countries has and will continue to put pressure on the pricing and usage of therapeutics such as our product candidates.

filing / Aug 5, 2026 / receipt

Our current international operations relate primarily to clinical trial activities, but our business plans incorporate potential international expansion, for example including the potential engagement with a collaborator based internationally, or upon any of our product candidates receiving regulatory approval (which may never occur).

filing / Aug 5, 2026 / receipt

Any of these factors, among others, could significantly limit or harm our future international expansion and operations and, consequently, our results of operations.

filing / Aug 5, 2026 / receipt

The Company currently also leases office space in Cambridge, Massachusetts and New York, New York, pursuant to short-term arrangements.

filing / Aug 5, 2026 / receipt

Other significant general and administrative expenses include legal fees relating to intellectual property and corporate matters, professional fees for accounting, tax and consulting services, insurance costs, travel expenses and facility related expenses not otherwise included in research and development expenses.

filing / May 15, 2026 / receipt

If we are unable to raise capital, we will need to delay, reduce or terminate some or all planned activities to reduce costs.

filing / May 15, 2026 / receipt

Outside the United States, international operations are generally subject to extensive governmental price controls and other market regulations, and we believe the increasing emphasis on cost containment initiatives in Europe, Canada and other countries has and will continue to put pressure on the pricing and usage of therapeutics such as our product candidates.

filing / May 15, 2026 / receipt

We currently have limited international operations, but our business plans incorporate potential international expansion, including the planned addition of international clinical trial sites, potential engagement with a collaborator based internationally, or if any of our product candidates receives regulatory approval.

filing / May 15, 2026 / receipt

Any of these factors, among others, could significantly limit or harm our future international expansion and operations and, consequently, our results of operations.

filing / May 15, 2026 / receipt

The Company currently also leases office space in Cambridge, Massachusetts and New York, New York, pursuant to short-term arrangements.

filing / May 15, 2026 / receipt