General and administrative expenses consist of personnel and related benefit expense, stock‑based compensation expense, employee travel expense, legal and accounting fees, rent and facilities expense, and management consulting expense.

filing / Aug 19, 2026 / receipt

This decrease was primarily driven by the normalization of recruiting and placement fees following the Gelclair commercial launch, alongside lower transportation, meals, and lodging costs attributable to a reduced employee headcount.

filing / Aug 19, 2026 / receipt

Jaguar family companies Napo and Napo Therapeutics, S.p.A., an Italian corporation Jaguar established in Milan, Italy in 2021, are focused on expanding global crofelemer access and are developing new therapies for orphan and rare GI conditions.

filing / Aug 19, 2026 / receipt

Based on the number of outbreaks and their geographic expansion, alongside the shortage of vaccines and other resources, WHO continues to assess the risk at the global level as very high and the event remains classified as a grade 3 emergency.

filing / Aug 19, 2026 / receipt

As of June 30, 2026, the Company holds several lease agreements, including two San Francisco office leases: Suite 400 and Suite 600.

filing / Aug 19, 2026 / receipt

• Personnel and related benefits decreased by $698,000 from $3.0 million for the six months ended June 30, 2025 to $2.3 million in the same period in 2026, due to a reduction in force (RIF) within the Clinical and QA groups, which resulted in lower headcount for clinical trial, research, and quality assurance functions during the period.

filing / Aug 19, 2026 / receipt